As a general marker of overall health status, few tests carry greater predictive weight then Homocysteine. The amount of Homocysteine in your blood is one of the best independent indicators of how healthy you are.
Axis-Shield launched the first immunoassay for Homocysteine and we are still at the forefront of promoting this vital marker with our new Enzymatic assay for use on laboratory clinical chemistry platforms.
For more information please visit our product website at www.homocysteine.org.uk
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The Liquid Stable (LS) 2-Part Enzymatic Homocysteine assay is intended for in vitro quantitative determination of total homocysteine in human serum and plasma.
In the Axis-Shield Enzymatic Homocysteine assay, bound or dimerised homocysteine (oxidised form) is reduced to free homocysteine, which then reacts with serine catalysed by cystathionine beta-synthase (CBS) to form L-cystathionine. Cystathionine in turn is broken down by cystathionine beta-lyase (CBL) to form homocysteine, pyruvate and ammonia. Pyruvate is then converted by lactate dehydrogenase (LDH) to lactate with NADH as coenzyme. The rate of NADH conversion to NAD is directly proportional to the concentration of homocysteine.
EDTA plasmas run in duplicate on the Roche Integra 800 over 20 days according to CLSI EP5-A2:
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A pioneering organisation focused on the development and manufacturing of important and innovative in vitro diagnostic tests for use in clinical laboratories.
As a general marker of overall health status, few tests carry greater predictive weight than Homocysteine. The amount of Homocysteine in your blood is one of the best independent indicators of how healthy you are.