The measurement of anti-CCP antibodies has become the method of choice in the accurate diagnosis of Rheumatoid Arthritis.
Assays using the second-generation CCP2 peptide are as sensitive as the rheumatoid factor test but with much higher specificity. Additionally anti-CCP2 positivity can predict future development of RA in both asymptomatic individuals and in patients with undifferentiated arthritis. It has also been shown that antibody levels at presentation can correlate with progression to erosive disease.
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12 x 8 well breakapart microtitre strips
Reference and positive/negative controls
The wells of the Axis-Shield anti-CCP microtitre strips are coated with highly-purified synthetic cyclic citrullinated peptides containing modified arginine residues (CCP2). In the quantitative protocol, the antibody concentration in an unknown sample can be estimated by interpolation from a dose response curve based on reference standards. In the qualitative protocol, the response measured in the unknown sample is compared to that of the known concentration reference control.
Sensitivity 78%, Specificity 99%
Total Imprecision <11%, Intra-assay imprecision <9%
Linear from 1.04 to 300 U/mL
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The assay is also available on Abbott's AxSYM and ARCHITECT platforms and through Bio-Rad's BioPlex 2200 multianalyte system and the Zenit RA system from Menarini. It is also planned for launch on Siemens Centaur analyser and on Beckman Coulter systems
*Products may not be approved for sale in all countries. Please contact us for further details.
A pioneering organisation focused on the development and manufacturing of important and innovative in vitro diagnostic tests for use in clinical laboratories.
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