Our Vision is to improve healthcare as a global provider of innovative and reliable diagnostic tests.
Our Mission is to identify and develop novel patentable diagnostic markers and technologies which can be commercialised to meet clinical needs, both in the laboratory and at the point of care.
We will collaborate with partners, create branded products and identify complementary businesses which support our objective of continuing to grow as a respected and profitable healthcare company.
Our Values include meeting all current and future regulatory, quality and environmental standards appropriate for our industry and the countries in which we operate.

Anti-CCP ELISA

The measurement of anti-CCP antibodies has become the method of choice in the accurate diagnosis of Rheumatoid Arthritis.

Assays using the second-generation CCP2 peptide are as sensitive as the rheumatoid factor test but with much higher specificity. Additionally anti-CCP2 positivity can predict future development of RA in both asymptomatic individuals and in patients with undifferentiated arthritis. It has also been shown that antibody levels at presentation can correlate with progression to erosive disease.

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Kit Components:
12 x 8 well breakapart microtitre strips

Reference and positive/negative controls

Sample diluent

6 calibrators

Wash buffer

IgG-HRP conjugate

Substrate

Stop solution.

Assay Technology:
The wells of the Axis-Shield anti-CCP microtitre strips are coated with highly-purified synthetic cyclic citrullinated peptides containing modified arginine residues (CCP2). In the quantitative protocol, the antibody concentration in an unknown sample can be estimated by interpolation from a dose response curve based on reference standards. In the qualitative protocol, the response measured in the unknown sample is compared to that of the known concentration reference control.

Performance:
Sensitivity 78%, Specificity 99%

Total Imprecision <11%, Intra-assay imprecision <9%

Linear from 1.04 to 300 U/mL

For more information please click here to download our brochure.

The assay is also available on Abbott's AxSYM and ARCHITECT platforms and through Bio-Rad's BioPlex 2200 multianalyte system and the Zenit RA system from Menarini. It is also planned for launch on Siemens Centaur analyser and on Beckman Coulter systems

*Products may not be approved for sale in all countries. Please contact us for further details.

Axis-Shield at a Glance

A pioneering organisation focused on the development and manufacturing of important and innovative in vitro diagnostic tests for use in clinical laboratories and at the point of care.

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Focus on Afinion

Axis-Shield's award winning point-of-care test system is designed for maximum simplicity coupled with laboratory accuracy and reliability for a number of key markers important for improved patient management.

› Afinion features